1-iodo-2.3-dihydroxypropane and process of making same.



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RICHARD m'jnnns, or STEGLITZ, GERMANY, ASSIGNOR 'ro FARIBWERKE vomu.MEISTER LUCIUS & 336mm 01 HooHstr-oN-THn-MAIN, GERMANY, A. CORPORATION.012

GERMANY.

. 1-IOD0-2.3-DIHYDROXYPROPANE AND PROCESS OF MAKING SAME.

No Drawing.

To all whom it may concern D., chemist, a citizen of the Empire of Be itknown that I, RICHARD Lr'ionns, Ph.

many, residing at Steglitz, near Berlin, Germany, have inventedcertainnew and useful Improvements in 1 Iodo-2.3-D1hydroxyproane and Processesof Making Same, of which the following is a specification.

I have found that by treating a-chlorhydrin with iodids of the alkalimetals a new compound is obtained, which is readily soluble in water andalcohol; it constitutes a thick oil which, when suiiiciently pure,solidifies so as to form a solid compound melting at 48-49 O. and towhich the constitution of a I iodo 2.3 dihydroxypropane ICH CH(OH) CH OHmust be attributed.

A pure and easily cryst'allizing product is obtained only if thereaction of the oc-chlorhydrin with the iodids of the alkali metalstakes place at a temperature not exceeding 90 C. and if the light isexcluded, because The following example illustrates my in' vention:

50 parts of oz-chlorhydrin are, digested in the dark at 30 35 C. forseveral days, while shaking, with 75 parts of dry, 'very finely powderedsodium-iodid. From the product of the reaction the iodohydroxypropanemay be isolated by first filtering off the salts and washing afterwardwith alcohol or ethyl acetate. From the filtrates, the washingagent isdistilled off and theresidue is then heated to about 75 C. as long asthere is still. separation of a salt. This is filtered and again washedin the manner above indicated. From the solution the alcohol andSpecification of Letters Patent. Application filed June 15, 1915. SerialNo. 34,193.

Ger-

Patented June 19, 1917.

the ethyl acetate respectively are distilled ofi", the residue, afterbeing. diluted with water, is decolorized by introducing sulfurous acidand the excess of the latter removedby a current of air, whereupon themass is extracted with ether and ethyl acetate and the solvents addedare distilled ofi.

readily soluble in Water, alcohol and ethyl acetate, lesssolubl'e inbenzene, which when standing in a vacuum over calcium chlorid formscrystals melting at 4849 C.

Having now described my invention, what I claim is:

1. The process of preparing 1-iodo-2.3-dil 'hydroxypropane, whichconsists in treating a-chlorhydrin with iodids of alkali metals,

. The residue thus obtained is a thick oil,

2. The process of preparing 1-iodo-2.3-dihydroxypropane, which consistsin treating oz-chlorhydrin with iodids of alkali metals at a temperaturenot exceeding 90' C.

3. ,The process of preparing 1-iodo-2.3-dihydroxypropane, which consistsin treating oz-chlorhydri'n with iodids of alkali metals at atemperature not exceeding 90 C. whileexcluding light.

4. The process of preparing 1-iodo-2.3-dihydroxypropane which consistsin treating a-chlorhydrin with sodium iodid.

5. The process of preparing 1-iodo-2.3-dihydroxypropane which consistsin treating a-chlorhydrin with sodium iodid at .a temperature notexceeding 90 (1., while excluding light.

6. As article of manufacture, the hereinbefore described new compound towhich the constitution of a l-iodo-2.3-dihydroxypropane may beattributed, being readily soluble in water, alcohol and ethyl-acetate,

less soluble in benzene, constituting a thick oil, which, whensuificiently pure, solidifies into crystals melting at 48-49 C.

Tn testimony whereof I aflix my signature in presence of two witnesses.v RICHARD LUDERS.

Witnesses:

WOLDEMAR HAUPT, HENRY HASPER.

